Kevin Esvelt, PhD

2004 Hertz Fellow
Visit website

Kevin Esvelt is an associate professor of media arts and sciences at the MIT Media Lab.

Esvelt is the director of the Sculpting Evolution group, which invents new ways to study and influence the evolution of ecosystems. By carefully developing and testing these methods with openness and humility, the group seeks to address difficult ecological problems for the benefit of humanity and the natural world.

Prior to joining the MIT Media Lab, Esvelt wove many different areas of science into novel approaches to ecological engineering. He invented phage-assisted continuous evolution (PACE), a synthetic microbial ecosystem for rapidly evolving biomolecules, in the laboratory of David R. Liu at Harvard University. At the Wyss Institute, he worked with George Church to develop the CRISPR system for genome engineering and regulation, and he began exploring the use of bacteriophages and conjugation to engineer microbial ecosystems.

Esvelt is credited as the first to describe how CRISPR gene drives could be used to alter the traits of wild populations in an evolutionarily stable manner. And recently, he and his Sculpting Evolution group devised a new form of technology, called ‘daisy drives’, which would let communities aiming to prevent disease alter wild organisms in local ecosystems.

By emphasizing universal safeguards and early transparency, he has worked to ensure that community discussions always precede and guide the development of technologies that will impact the shared environment.

Graduate Studies

Harvard University
Biology
A System for the Continuous Directed Evolution of Biomolecules

Undergraduate Studies

Harvey Mudd College

Awards

2004, Graduate Research Fellowship Program, National Science Foundation
2010, Hertz Thesis Prize, Fannie & John Hertz Foundation
2016, TR35, MIT Technology Review
2017, Director’s New Innovator Award, National Institutes of Health
2018, Sloan Research Fellow, Alfred P. Sloan Foundation

Related News

Aug 10, 2020
During the Hertz Foundation’s 2020 Summer Workshop, Hertz Fellows came together to shed light on the effects of COVID-19 on the nation's healthcare system and discuss new solutions that could offer up some relief amidst the throes of the global pandemic.
Oct 27, 2017
Hertz Foundation Fellows Recognized with 2017 NIH Director’s New Innovator Award, Transformative Research Award and Early Independence Award; Hertz Fellow Edward Boyden is the Most Honored Investigator with Five Awards Since 2007
Aug 29, 2017
Hertz Fellow Seeks to Improve Gene-Editing Safety, Efficiency and Reversibility to Prevent Unwanted Proliferation of Gene Drives
Feb 7, 2017
In a previous article on Kevin’s research, "Directed Evolution Drives Hertz Fellow Kevin Esvelt to Find Solutions to Vector-borne and Parasitic Diseases", this article is a follow-up on Kevin’s progress of real-world application of using CRISPR and his public policy outreach on open-community driven science with the community of Nantucket Island, in order to help find a solution to nearly eliminating their Lyme disease problem.
Dec 21, 2015
Hertz Fellow and evolutionary biologist Kevin Esvelt has identified a general way to combat vector-borne and parasitic scourges such as malaria, schistosomiasis, and dengue by altering entire populations of these wild organisms. The technique, called CRISPR (clustered regularly interspaced short palindromic repeats) gene drive, is an example of directing the natural process of evolution so that the resultant changes can benefit humanity for generations to come. Recently appointed as an assistant professor of the MIT Media Lab, Dr. Esvelt will lead the new Sculpting Evolution research group to explore ecological and evolutionary engineering.