Kyle M. Loh

Hertz Fellow: Kyle M. Loh
School

Stanford University

Area of Study

Stem Cell Biology

Fellowship Years

2011 - 2016

Our laboratory at the Stanford Institute for Stem Cell Biology & Regenerative Medicine and the Department of Developmental Biologyis focused on generating human tissue progenitors from embryonic stem cells and exploring their use in regenerative medicine (https://loh.stanford.edu/). To this end, we have delineated a comprehensive roadmap that describes how embryonic stem cells can develop into a spectrum of over twenty different human cell types. This roadmap enabled us to generate rather uniform populations of human liver progenitors, bone progenitors and heart progenitors from embryonic stem cells, each of which could generate their respective tissue upon injection into respective mouse models. This platform to produce these engraftable human tissue progenitors provides fundamental building blocks for regenerative medicine and provides an ideal venue to understand human developmental biology. In particular we are interested in questions regarding cellular signaling, developmental competence and tissue organization.

Kyle received his B.A. from Rutgers University, interned with Bing Lim at the Genome Institute of Singapore, and received his Ph.D. from Stanford University (working with Irving Weissman) as a fellow of the Hertz Foundation, the National Science Foundation and the Davidson Institute of Talent Development. He then continued research as the Siebel Investigator at the Stanford Institute for Stem Cell Biology & Regenerative Medicine, and later, as an Assistant Professor of Developmental Biology and The Anthony DiGenova Endowed Faculty Scholar. Kyle is a Packard Fellow, Pew Scholar, Human Frontier Science Program Young Investigator and Baxter Foundation Faculty Scholar, and his research has been recognized by the NIH Director's Early Independence Award, Forbes 30 Under 30, Harold Weintraub Graduate Award, Hertz Foundation Thesis Prize and the A*STAR Investigatorship.

Thesis:

2016 - A Developmental Roadmap for the Diversification of Human Tissue fates from Pluripotent Cells