Kyle M. Loh

Hertz Fellow: Kyle M. Loh
School

Stanford University

Area of Study

Stem Cell Biology

Fellowship Years

2011 - 2016

Kyle Loh is an assistant professor at the Stanford University School of Medicine. His laboratory at the Stanford Institute for Stem Cell Biology & Regenerative Medicine and the Department of Developmental Biology is focused on generating human tissue progenitors from embryonic stem cells and exploring their use in regenerative medicine.

As a Hertz Fellow, Kyle obtained his PhD in stem cell biology at Stanford, with added support from the National Science Foundation and the Davidson Institute for Talent Development. He investigated how different human tissues are formed as the body develops. By mapping this process of tissue development, his work has enabled the generation of pure populations of different human tissue progenitors (including liver progenitors, pancreas progenitors, intestinal progenitors, bone progenitors and heart progenitors) in a dish from embryonic stem cells. He has shown that these artificially generated human cells can regenerate human liver tissue or even a human bone in respective mouse models; as such they might be used to regenerate tissues in patients someday in the distant future.

Kyle’s research has been recognized by the NIH Director’s Early Independence Award (under the NIH High-Risk, High-Reward Research Program) and the Weintraub Graduate Award from the Fred Hutch Cancer Center. He also teaches classes in developmental and stem cell biology to PhD students and undergraduates. Kyle was formerly the Siebel Investigator at Stanford prior to being appointed an assistant professor.

Thesis:

2016 - A Developmental Roadmap for the Diversification of Human Tissue fates from Pluripotent Cells