Jeffrey Gore

Hertz Fellow: Jeffrey Gore
School

University of California, Berkeley

Area of Study

Biophysics

Fellowship Years

1999 - 2004

Jeff Gore, PhD, is an associate professor of physics at MIT, and leads Gore Laboratory, which is composed of an interdisciplinary group of scientists interested in learning from each other to effectively combine experiments, theory and modeling. Previously, he studied the evolution of cooperation in the laboratory of MIT Professor Alexander van Oudenaarden. The conditions required for the initiation and maintenance of cooperation is a classic problem in evolutionary biology with deep connections to game theory. Any evolutionary stable state between competing strategies must also be a Nash Equilibrium of the corresponding "game."

As a model system to explore competition and cooperation experimentally, Jeff is studying the metabolism of sucrose by yeast. The first step of the digestion of the disaccharide sucrose involves enzymatic breakdown of the molecule into its two constituent monosaccharides. This reaction is done outside the cell, making it possible for neighboring cells to "cheat" by consuming the monosaccharides created by other cells.

Jeff finished his undergraduate studies in physics, mathematics, and economics at MIT in 1999, and as a Hertz Fellow, obtained his PhD from the University of California, Berkeley, in 2005. His research in single-molecule biophysics was done in the laboratory of Carlos Bustamante, focusing on the study of twist and torque in single molecules of DNA.

Thesis:

2005 - Single-Molecule Studies of DNA Twist Mechanics and Gyrase Mechanochemistry