David Breslow

Hertz Fellow: David Breslow
School

University of California, San Francisco

Area of Study

Biotechnology

Fellowship Years

2005 - 2010

David Breslow is the Connie and Bob Lurie Fellow of the Damon Runyon Cancer Research Foundation and is working with Professor Maxence Nachury at Stanford University. In the Nachury lab, David is investigating the primary cilium, a recently rediscovered cellular structure that is thought to act as an antenna that enables cells to sense external cues and respond appropriately. In particular, David is interested in how specialized signaling proteins are trafficked to the cilium and how primary cilia organize signal transduction. In his doctoral work, he developed new tools to systematically and quantitatively identify functional relationships between genes. He also used this methodology to identify a novel protein family that enables cells to precisely match lipid synthesis to their metabolic need. After his postdoc, David plans to continue to pursue academic research.

Thesis:

2010 - Development of a High-Resolution Growth Assay for Yeast Functional Genomics and Identification of Orm Family Proteins as Key Mediators of Sphingolipid Homeostasis